DNA

Publications

In recent years, the Costello Lab has published research in a variety of academic journals, including Science, NatureNature Communications, and Cancer Cell. Below includes a featured selection of recent publications.

 

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

Stieglitz E, Mazor T, Olshen AB, Geng H, Gelston LC, Akutagawa J, Lipka DB, Plass C, Flotho C, Chehab FF, Braun BS, Costello JF , Loh ML.

Nat Commun. 2017 Dec 19; 8 (1): 2127.
PubMed Link >

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1.

Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF.

Proc Natl Acad Sci U S A. 2017 Oct 3; 114 (40): 10743-10748. doi: 10.1073/pnas.1708914114. Epub 2017 Sep 15.
PubMed Link >

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

Kohanbash G, Carrera DA, Shrivastav S, Ahn BJ, Jahan N, Mazor T, Chheda ZS, Downey KM, Watchmaker PB, Beppler C, Warta R, Amankulor NA, Herold-Mende C, Costello JF, Okada H

J Clin Invest. 2017 Apr 3; 127 (4): 1425-37. doi: 10.1172/JCI90644. Epub 2017 Mar 20.
PubMed Link >

Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide

Wahl M, Phillips JJ, Molinaro AM, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM

Neuro Oncol. 2017 Feb 1; 19 (2): 242-51. doi: 10.1093/neuonc/now176.
PubMed Link >

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process

Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO

Cancer Res. 2016 Nov 15; 76 (22): 6680-6689. doi: 10.1158/0008-5472.CAN-16-0696. Epub 2016 Oct 6.
PubMed Link >

Understanding TERT Promoter Mutations: A Common Path to Immortality

Bell RJ, Rube HT, Xavier-Magalhães A, Costa BM, Mancini A, Song JS, Costello JF

Mol Cancer Res. 2016; 14 (4): 315-23. doi: 10.1158/1541-7786.MCR-16-000.
PubMed Link >

Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Viswanath P, Najac C, Izquierdo-Garcia JL, Pankov AHong C, Eriksson P, Costello JF, Pieper RO, Ronen SM

Oncotarget. 2016 Jun 7; 7 (23): 34942-55. doi: 10.18632/oncotarget.9006.
PubMed Link >

Cancer: Oncogene brought into the loop

Grimmer MRCostello JF

Nature. 2016 Jan 7; 529 (7584): 34-5. doi: 10.1038/nature16330. Epub 2015 Dec 23.
PubMed Link >

The genomic landscape of juvenile myelomonocytic leukemia

Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen S, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber T Golub T, Stegmaier K, Loh ML.

Nat Genet. 2015; 47 (11): 1326-1333. doi: 0.1038/ng.3400. Epub 2015 Oct 12.
PubMed Link >

DNA methylation and somatic mutations converge on cell cycle and define similar evolutionary histories in brain tumors

Mazor T*Pankov A*Johnson BEHong CHamilton EGBell RJ, Smirnov IV, Reis GF, Phillips JJ, Barnes M, Idbaih A, Alentorn A, Kloezeman JJ, Lamfers ML, Bollen AW, Taylor BS, Molinaro AM, Olshen OB, Chang SM, Song JS, Costello JF

Cancer Cell. 2015 Sep 14; 28 (3): 307-317. doi: 10.1016/j.ccell.2015.07.012.
PubMed Link >

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

Bell RJ, Rube HT, Krieg A, Mancini AFouse SDNagarajan RPChoi SHong CHe D, Pekmezci M, Wiencke JK, Wrensch MR, Chang SM, Walsh KM, Myong S, Song JS, Costello JF

Science. 2015 May 29; 348 (6238): 1036-9. doi: 10.1126/science.aab0015. Epub 2015 May 14.
PubMed Link >

The genetics of splicing in neuroblastoma

Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA.

Cancer Discov. 2015; 5 (4): 380-95. doi: 10.1158/2159-8290.CD-14-0892. Epub 2015 Jan 30.
PubMed Link >

Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment

van Thuijl HFMazor TJohnson BEFouse SD, Aihara K, Hong C, Malmström A, Hallbeck M, Heimans JJ, Kloezeman JJ, Stenmark-Askmalm M, Lamfers ML, Saito N, Aburatani H, Mukasa A, Berger MS, Söderkvist P, Taylor BS, Molinaro AM, Wesseling P, Reijneveld JC, Chang SM, Ylstra B, Costello JF

Acta Neuropathol. 2015; 129 (4): 597-607. doi: 10.1007/s00401-015-1403-6. Epub 2015 Feb 28.
PubMed Link >

Integrative analysis of 111 reference human epigenomes

Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M

Nature. 2015 Feb 19; 518 (7539): 317-30. doi: 10.1038/nature14248.
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Epigenetic and transcriptional determinants of the human breast

Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RPHong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JBNeel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M

Nat Commun. 2015 Feb 15; 6: 6351. doi: 10.1038/ncomms7351.
PubMed Link >