DNA

Publications

In recent years, the Costello Lab has published research in a variety of academic journals, including Science, Nature, Nature Communications, and Cancer Cell. Below includes a featured selection of recent publications.

 

miRNA-independent function of long noncoding pri-miRNA loci.

He D, Wu D, Muller S, Wang L, Saha P, Ahanger SH, Liu SJ, Cui M, Hong SJ, Jain M, Olson HE, Akeson M, Costello JF, Diaz A, Lim DA. 

Proc Natl Acad Sci U S A. . Mar 21; 118 (13): PMCID: PMC8020668.
PubMed Link >

Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology.

Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. 

Neuro Oncol.. Mar 25; PMCID: PMC7992879.
PubMed Link >

Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma. Metabolites.

Radoul M, Hong D, Gillespie AM, Najac C, Viswanath P, Pieper RO, Costello JF, Luchman HA, Ronen SM. 

Metabolites. 2021 Feb 13; 11: PMCID: PMC7917625.
PubMed Link >

Epigenomic contributions to tumor cell heterogeneity and plasticity.

Mathur R, Costello JF. 

Nat Genet. . 2021 Jul 5; 10 (53): 1403-1404. doi: 10.1038/s41588-021-00932-w.
PubMed Link >

Non-invasive assessment of telomere maintenance mechanisms in brain tumors

Viswanath P, Batsios G, Mukherjee J, Gillespie AM, Larson PEZ, Luchman HA, Phillips JJ, Costello JF, Pieper RO, Ronen SM
Nat Commun. 2021; 12 (1): 92. doi: 10.1038/s41467-020-20312-y.
PubMed Link >

Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non- neuro-oncology experts in cancer immunology

Chuntova P, Chow F, Watchmaker P, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown C, Chen Y, Fecci P, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H

Neuro Oncol. 2020 Feb 8; doi: 10.1093/neuonc/noaa277.
PubMed Link >

Prostate cancer progression and the epigenome

Arap W, Pasqualini R, Costello JF

N Engl J Med. 2020; 383 (23): 2287-2290. doi: 10.1056/NEJMcibr2030475.
PubMed Link >

Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma

Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR

Nat Commun. 2020; 11 (1): 4803. doi: 10.1038/s41467-020-18582-7.
PubMed Link >

Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma

Jones LE, Hilz S, Grimmer MR, Mazor T, Najac C, Mukherjee J, McKinney A, Chow T, Pieper RO, Ronen SM, Chang SM, Phillips JJ, Costello JF

Neurooncol Adv. 2020; 2 (1): doi: 10.1093/noajnl/vdaa088.
PubMed Link >

The DNA methylation landscape of advanced prostate cancer

Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY

Nat Genet. 2020; 52 (8): 778-789. doi: 10.1038/s41588-020-0648-8. Epub 2020 Jul 13. PMID: 32661416.
PubMed Link >

Epigenomic programming in early fetal brain development

Li L, Maire CL, Bilenky M, Carles A, Heravi-Moussavi A, Hong C, Tam A, Kamoh B, Cho S, Cheung D, Li I, Wong T, Nagarajan RP, Mungall AJ, Moore R, Wang T, Kleinman CL, Jabado N, Jones SJ, Marra MA, Ligon KL, Costello JF, Hirst M

Epigenomics. 2020 Feb 8; 12 (12): 1053-1070. doi: 10.2217/epi-2019-0319. Epub 2020 Jul 17. PMID: 32677466..
PubMed Link >

Functional analysis of low-grade glioma genetic variants predicts key target genes and transcription factors

Manjunath M, Yan J, Youn Y, Drucker KL, Kollmeyer TM, McKinney AM, Zazubovich V, Zhang Y, Costello JF, Eckel-Passow J, Selvin PR, Jenkins RB, Song JS

Neuro Oncol. 2020; doi: 10.1093/neuonc/noaa248.
PubMed Link >

MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence

Radhika Mathur, Yalan Zhang, Matthew R Grimmer, Chibo Hong, Michael Zhang, Saumya Bollam, Kevin Petrecca, Jennifer Clarke, Mitchel S Berger, Joanna J Phillips, Nancy Ann Oberheim-Bush, Annette M Molinaro, Susan M Chang, Joseph F Costello 

Neuro-Oncology. 2020; 22 (11): 1580–1590. doi: https://doi.org/10.1093/neuonc/noaa059.
PubMed Link >

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF

Cancer Cell. 2018 Sep 10; 34 (3): 513-528.e8. doi: 10.1016/j.ccell.2018.08.003.
PubMed Link >

Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas

Hayes J*, Yu Y*, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang SM, Nelson SJ, Woehrer A, Phillips JJ, Solomon DA, Costello JF

Neuro Oncol. 2018 Apr 9; 20 (5): 632-641. doi: 10.1093/neuonc/nox205.
PubMed Link >