In recent years, the Costello Lab has published research in a variety of academic journals, including Science, NatureNature Communications, and Cancer Cell. Below includes a featured selection of recent publications.


Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective

Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF.

Cell. 2024 Jan 18; 187 (2): 446-463.e16. doi: 10.1016/j.cell.2023.12.013.
PubMed Link >

Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects.

Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK.

J Clin Invest. 2023 Mar 1; 133 (5): e147087. doi: 10.1172/JCI147087.
PubMed Link >

Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.

Batsios G, Taglang C, Tran M, Stevers N, Barger C, Gillespie AM, Ronen SM, Costello JF, Viswanath P.

Clin Cancer Res. 2022 Aug 15; 28 (15\6): 3526-3536. doi: 10.1158/1078-0432.CCR-21-4418.
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Glioma progression is shaped by genetic evolution and microenvironment interactions.

Varn FS, Johnson KC, Martinek J, Huse JT, Nasrallah MP, Wesseling P, Cooper LAD, Malta TM, Wade TE, Sabedot TS, Brat D, Gould PV, Wöehrer A, Aldape K, Ismail A, Sivajothi SK, Barthel FP, Kim H, Kocakavuk E, Ahmed N, White K, Datta I, Moon HE, Pollock S, Goldfarb C, Lee GH, Garofano L, Anderson KJ, Nehar-Belaid D, Barnholtz-Sloan JS, Bakas S, Byrne AT, D'Angelo F, Gan HK, Khasraw M, Migliozzi S, Ormond DR, Paek SH, Van Meir EG, Walenkamp AME, Watts C, Weiss T, Weller M, Palucka K, Stead LF, Poisson LM, Noushmehr H, Iavarone A, Verhaak RGW; GLASS Consortium.

Cell. 2022 Jun 9; 185 (12): 2184-2199. doi: 10.1016/j.cell.2022.04.038. Epub 2022 May 31.
PubMed Link >

GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer.

McKinney AM, Mathur R, Stevers NO, Molinaro AM, Chang SM, Phillips JJ, Costello JF. 

Cell Rep. 2022 Sep 20; 40 (12): 111344. doi: 10.1016/j.celrep.2022.111344. PMID: 36130485.
PubMed Link >

Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer.

Barger CJ, Suwala AK, Soczek KM, Wang AS, Kim MY, Hong C, Doudna JA, Chang SM, Phillips JJ, Solomon DA, Costello JF.

Nat Commun. 2022 Sep 16; 13 (1): 5430. doi: 10.1038/s41467-022-33099-x. PMID: 36114166.
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Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.

Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon DA. 

Acta Neuropathol. 2022 Oct 1; 144 (4): 747-765. doi: 10.1007/s00401-022-02478-5. Epub 2022 Aug 9..
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Imaging biomarkers of TERT or GABPB1 silencing in TERT-positive glioblastoma.

Minami N, Hong D, Stevers N, Barger CJ, Radoul M, Hong C, Chen L, Kim Y, Batsios G, Gillespie AM, Pieper RO, Costello JF, Viswanath P, Ronen SM. 

Neuro Oncol. . 2022 Apr 23; PMID: 35460557.
PubMed Link >

TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo.

Miki S, Koga T, Mckinney AM, Parisian AD, Tadokoro T, Vadla R, Masala M, Hevner RF, Costello JF, Furnari F. 

Neuro Oncol. . 2022 Mar 23; PMID: 35325218.
PubMed Link >

PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications. Neuro Oncol.

Mohamed E, Kumar A, Zhang Y, Wang AS, Chen K, Lim Y, Shai A, Taylor JW, Clarke J, Hilz S, Berger MS, Solomon DA, Costello JF, Molinaro AM, Phillips JJ. 

Neuro Oncol.. 2022 Mar 14; PMID: 35287169.
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The Placenta - Fast, Loose, and in Control.

Costello JF, Fisher SJ.

N Engl J Med. . 2021 Jul 1; 385(1):87-89: PMID: 34192437..
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Spatial concordance of DNA methylation classification in diffuse glioma.

Verburg N, Barthel FP, Anderson KJ, Johnson KC, Koopman T, Yaqub MM, Hoekstra OS, Lammertsma AA, Barkhof F, Pouwels PJW, Reijneveld JC, Rozemuller AJM, Beliën JAM, Boellaard R, Taylor MD, Das S, Costello JF, Vandertop WP, Wesseling P, de Witt Hamer PC, Verhaak RGW. 

Neuro Oncol.. 2021 May 8; PMID: 34049406.
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Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease.

Zhang B, Kim MY, Elliot G, Zhou Y, Zhao G, Li D, Lowdon RF, Gormley M, Kapidzic M, Robinson JF, McMaster MT, Hong C, Mazor T, Hamilton E, Sears RL, Pehrsson EC, Marra MA, Jones SJM, Bilenky M, Hirst M, Wang T, Costello JF, Fisher SJ. 

Dev Cell.. 2021 Apr 20; PMID: 33891899.
PubMed Link >

Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas.

Viswanath P, Batsios G, Ayyappan V, Taglang C, Gillespie AM, Larson PEZ, Luchman HA, Costello JF, Pieper RO, Ronen SM. 

Neuro Oncol. . 2021 Apr 17; PMID: 33864084.
PubMed Link >

Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas.

Yu Y, Villanueva-Meyer J, Grimmer MR, Hilz S, Solomon DA, Choi S, Wahl M, Mazor T, Hong C, Shai A, Phillips JJ, Wainer BH, McDermott M, Haas-Kogan D, Taylor JW, Butowski N, Clarke JL, Berger MS, Molinaro AM, Chang SM, Costello JF, Oberheim Bush NA. 

Neuro Oncol.. 2021 Apr 12; 23 (4): 638-649. PMCID: PMC8041333.
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