Genomics and Epigenomics of Glioma Progression
Using samples taken from MRI-guided glioma biopsies, we are using whole exome and whole methylome sequencing to elucidate the evolutionary histories of tumor genomes and epigenomes. Recent work conducted in the lab has shown that spatial and temporal patterns of DNA methylation and somatic mutations during the progression of low-grade gliomas to high-grade tumors produce remarkably similar evolutionary histories and both converge to deregulate the cell cycle.
Mazor T*, Pankov A*, Johnson BE, Hong C, Hamilton EG, Bell RJ, Smirnov IV, Reis GF, Phillips JJ, Barnes M, Idbaih A, Alentorn A, Kloezeman JJ, Lamfers ML, Bollen AW, Taylor BS, Molinaro AM, Olshen OB, Chang SM, Song JS, Costello JF. DNA methylation and somatic mutations converge on cell cycle and define similar evolutionary histories in brain tumors. Cancer Cell. 2015 Sep 14; 28(3):307-1.
Who works on this project in the lab?