Giselle Y. López, MD, PhD
I am interested in tumor heterogeneity, and am currently exploring tumor heterogeneity in oligodendroglioma and its relationship to tumor progression.
Dr. López is currently faculty at The Preston Robert Tisch Brain Tumor Center at Duke University.
2005: BS, Physiology and Neurobiology, University of Maryland, College Park
2005: BA, Spanish Language and Literature, University of Maryland, College Park
2014: MD, Duke University
2014: PhD, Department of Pathology, Duke University
2014-2016: Pathology Resident, Department of Pathology, UCSF
2016-2018: Neuropathology Fellow, Department of Pathology, UCSF
2018-Present: Clinical Research Fellow, Division of Neuropathology, Department of Pathology, UCSF
2005: University Medal Finalist, University of Maryland
2011: Minority Scholar in Cancer Research Award, American Association for Cancer Research
2018: Society of '67 Scholars Travel Award, Association of Pathology Chairs
2018: Award for Excellence and Innovation in Graduate Medical Education, University of California, San Francisco
The genetic landscape of gliomas arising after therapeutic radiation
López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA.
Acta Neuropathol. 2018 Sept 8. doi: 10.1007/s00401-018-1906-z. [Epub ahead of print]
CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma
López GY, Perry A, Harding B, Li M, Santi M
Neuropathol Appl Neurobiol. 2018 May 27. doi: 10.1111/nan.12503. [Epub ahead of print]
Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression
Lopez GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon DA.
Acta Neuropathol. 2017 Dec;134(6):961-963. doi: 10.1007/s00401-017-1780-0. Epub 2017 Oct 23.
Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma
López G, Oberheim Bush NA, Berger MS, Perry A, Solomon DA.
Acta Neuropathol Commun. 2017 May 15; 5(1):38. doi: 10.1186/s40478-017-0440-x.
Supratentorial tanycytic ependymoma in an adult male: case report and review of literature
López G, McLendon RE, Peters KB.
Case Rep Oncol. 2015 Mar 12; 8(1):159-63. doi: 10.1159/000380906. eCollection 2015 Jan-Apr.
EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis
Feng H, López G, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY.
J Clin Invest. 2014 Sept; 124(9):3741-56. doi: 10.1172/JCI73093. Epub 2014 Jul 25.
Transcriptional regulation of N-acetylglutamate synthase
Heibel SK, López GY, Panglao M, Sodha S, Mariño-Ramírez L, Tuchman M, Caldovic L.
PLoS One. 2012; 7(2):e29527. doi: 10.1371/journal.pone.0029527. Epub 2012 Feb 27.
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
Koivunen P, Lee S, Duncan CG, López G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr.
Nature. 2012 Feb 15; 438(7390):484-8. doi: 10.1038/nature10898.
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain
López GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon RE, Rosenberg SA, Samuels Y, Yan H.
Biochem Biophys Res Commun. 2010 Jul 30; 398(3):585-7. doi: 10.1016/j.bbrc.2010.06.125. Epub 2010 Jul 13.