Ana Xavier-Magalhães, PhD
Research Interests: Regulation and therapeutic targeting of TERT promoter mutations in glioblastoma
Other Interests: Cooking and baking, swimming, travelling, scuba diving and snorkeling
Email: Ana.DaSilvaDeMagalhaes@ucsf.edu
I study the effects of the protein, GABPβ1L, on regulation of the mutant TERT promoter, and its impact on cell immortality. I am exploring a therapeutic approach in glioblastoma patient-derived cell cultures to specifically target the mutant TERT promoter, which should limit effects on non-cancerous cells.
2018-Present: Postdoctoral Scholar (UCSF)
2017: PhD in Health Sciences, University of Minho, Life and Health Sciences Research Institute (ICVS), Portugal (2012-2015) and University of California, San Francisco (UCSF), Dept. of Neurological Surgery (2015-2017)
2012: MSc in Molecular Genetics, University of Minho, School of Sciences, Portugal
2010: BS in Biochemistry, University of Minho, School of Sciences, Portugal
2009-2010: Integration into Research Fellowship, Center of Molecular and Environmental Biology, University of Minho, Portugal
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA1, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF
Cancer Cell. 2018 Sept 10;34(3):513-528.e8. doi: 0.1016/j.ccell.2018.08.003.
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma
Xavier-Magalhães A, Gonçalves CS, Fogli A, Lourenço T, Pojo M, Pereira B, Rocha M, Lopes MC, Crespo I, Rebelo O, Tão H, Lima J, Moreira R, Pinto AA, Jones C, Reis RM, Costello JF, Arnaud P, Sousa N, Costa BM.
Oncotarget. 2018 Feb 28;9(21):15740-15756. doi: 10.18632/oncotarget.24597. eCollection 2018 Mar 20.
Influence of HOTAIR rs920778 and rs12826786 genetic variants on prostate cancer risk and progression-free survival
Oliveira AI, Xavier-Magalhães A, Moreira-Barbosa C, Magalhães H, Henrique R, Jerónimo C, Costa BM.
Biomark Med. 2018 Mar;12(3):257-264. doi: 10.2217/bmm-2017-0258. Epub 2018 Feb 13.
Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis
Xavier-Magalhães A, Oliveira AI, de Castro JV, Pojo M, Gonçalves CS, Lourenço T, Viana-Pereira M, Costa S, Linhares P, Vaz R, Nabiço R, Amorim J, Pinto AA, Reis RM, Costa BM.
J Neurooncol. 2017 Mar;132(1):27-34. doi: 10.1007/s11060-016-2345-0. Epub 2017 Jan 12.
Understanding TERT Promoter Mutations: A Common Path to Immortality
Bell RJ, Rube HT, Xavier-Magalhães A, Costa BM, Mancini A, Song JS, Costello JF.
Mol Cancer Res. 2016 Apr;14(4):315-23. doi: 10.1158/1541-7786.MCR-16-0003. Epub 2016 Mar 3.
Molecular prognostic factors in glioblastoma: state of the art and future challenges
Xavier-Magalhães A, Nandhabalan M, Jones C, Costa BM.
CNS Oncol. 2013 Nov;2(6):495-510. doi: 10.2217/cns.13.48.